Latest Autism News
Two new studies, one in individuals with Fragile X syndrome and the other a mouse model study may offer some hope. It is far too early to tell whether these findings are really relevant to the lives of many kids with ASDs, but it worth taking a look. Berry-Kravis and colleagues, tested arbaclofen, a drug that binds to the GABA-B receptors in the brain, with 63 individuals, ages 6 to 39 diagnosed with Fragile X syndrome. There is about a 25% overlap between Fragile X and autism. Half were randomly assigned to arabaclofen and half were given placebos. There was significant improvement in social function in a subgroup of 27 patients with more severe social impairment. There were a few side effects, including hives (13%) and headaches (8%). Arabaclofen is a close relative of the drug baclofen used for treating spastic muscular disabilities. It is important to bear in mind that the participants were diagnosed with Fragile X syndrome, not autism, though there is considerable overlap in some of the symptoms. In the other study on genetics and behavior of a mouse model of some forms of autism by Baudouin and collegues. They found differences in Neuroligin-3 receptors in brain were associated with social behavioral differences in mice. Neuroligin plays a role in forming synapses in the brain. It is unknown whether the behavioral measures in mice are actually correlated with social behavior in people. Mutations of Neuroligin are rare in humans and at most would account for a tiny fraction of autism cases.
Berry-Kravis EM et. Al. (20120 Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial. Sci Transl Med. 2012 Sep 19;4(152):152ra127.
Baudouin, SJ et. Al. (2012) Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism. Science. 2012 Sep 13. [Epub ahead of print]
Two other new studies summarized on my Autism Treatment website indicate frequency of gastrointestinal problems are no greater among kids with PDD-NOS than typical peers and that Hyperbaric Oxygen treatment produces no measurable improvements. www.travisithompson.net
Quick fixes are nearly always illusory. There are no magical mystery cures. As with any other child, learning new skills and behavior changes among youngsters with autism comes gradually with loving patience and parenting consistency. The psychiatrist Carl Jung said it well, "If there is anything we wish to change in the child, we should first examine it and see whether it is not something that could be better changed in ourselves." Integration of Personality (1939). Put another way, changing a child's behavior almost always requires changing what we do as parents.
There is a connection between musical interest and talent and autism spectrum disorders as noted originally by Leo Kanner as well as in Oliver Sachs’s book, Musicophilia. September 25, 1932 Glenn Gould was born in Toronto, CA, a pianist who became one of the best-known and most celebrated classical pianists of the 20th century. He is alleged to rarely practice, instead he claimed to “hear the music in his head,” from studying sheet music. He hated performing. He was prone to behavior most considered very odd, such as cancelling a performance at the last minute and humming while performing, and wearing heavy clothing including gloves during distinctively warm weather. He had numerous rigid, unusual mannerisms and behavior patterns. Though not officially diagnosed, many experts have considered Mr. Gould to having had Asperger disorder.
What I’m Up To
I’m in the final planning stages for a nine day trip to Paris in a few weeks to present workshops to the ÉCLAIR organization [Education Comportementale et Ludique vers une Autonomie et une Intégration Réussie] Training inclusive, for parents and autism professionals, which consists of parents and professionals providing behavioral services to children with autism in France. I’ll also be meeting with another family organization. One day-long workshop will focus on Early Behavioral Intervention in Autism, including alternatives and brain changes underlying treatment effectiveness. Other presentations will include Obsessive Compulsive Behavior in Autism, and Freedom From Meltdowns.
Quote of the Week
During this time of ferocious Republican attacks upon American public education, it is worth remembering how important public education is to children with autism, and that among the very first concerns of our ancestors was public education. The first American schools in the thirteen original colonies opened in the 17th century. Boston Latin School was founded in 1635 and is the first public school in the United States. Public education was mandatory in the Massachusetts Bay Colony beginning 1638. Thomas Jefferson wrote in a letter to Joseph C. Cabell, January 14, 1818 "A system of general instruction, which shall reach every description of our citizens from the richest to the poorest, as it was the earliest, so will it be the latest, of all the public concerns in which I shall permit myself to take an interest.” [Boyd, Julian P., Charles T. Cullen, John Catanzariti, Barbara B. Oberg, et al, eds. The Papers of Thomas Jefferson. Princeton: Princeton University Press, 1950-. 33 vols.]